Templated assembly of ph-labile polymer-drug particles for intracellular drug delivery

J Cui; Y Yan; Y Wang; F Caruso

Journal article

Templated assembly of ph-labile polymer-drug particles for intracellular drug delivery

J Cui, Y Yan, Y Wang, F Caruso

Advanced Functional Materials | Published : 2012

DOI: 10.1002/adfm.201201191

Download PDF

Abstract

The preparation of pH-labile polymer-drug particles via mesoporous silica-templated assembly for anticancer drug delivery into cancer cells is reported. The polymer-drug conjugate is synthesized via thiol-maleimide click chemistry using thiolated poly(methacrylic acid) (PMA SH) and a pH-labile doxorubicin (Dox) derivative. Drug-loaded polymer particles that are stable under physiological conditions are obtained through infiltration of the conjugates into mesoporous silica particles, followed by cross-linking the PMA SH chains, and subsequent removal of the porous silica templates. The encapsulated Dox is released from the particles through cleavage of the hydrazone bonds between Dox and PMA ..

View full abstract

University of Melbourne Researchers

Frank Caruso Author

Related Projects (4)

COLORECTAL CANCER - MOLECULAR BASIS TO TARGETED THERAPEUTICS

Cancer of the colon and rectum is the most common form of cancer in Australia. Over 12,000 people are diagnosed each year with colorectal ca..

COLORECTAL CANCER - MOLECULAR BASIS TO TARGETED THERAPEUTICS

Cancer of the colon and rectum is the most common form of cancer in Australia. Over 12,000 people are diagnosed each year with colorectal ca..

BUILDING MOLRCULARY ENGINEERED POLYMER NANOMATERIALS

The development of new technologies at the interface between nano- and biotechnology promises to revolutionise healthcare and medicine. This..

NANOENGINEERED POLYMERIC MATERIALS FOR ENVIRONMENTAL AND BIOLOGICAL APPLICATIONS

The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and h..

Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council under the Federation Fellowship and Discovery Project schemes (F. C.), and a National Health and Medical Research Council (NHMRC) Program Grant 487922 (F. C.). J.C. is the recipient of an Australian Research Council Super Science Fellowship (FS110200025). The authors thank K. Liang for CLSM images and R. Chandrawati for assistance regarding the thiol-disulfide chemistry. G. K. Such is also thanked for helpful discussions.